This Viewpoint reviews what is known about acute and long-term B-cell, antibody, and T-cell responses to SARS-CoV-2 infection and explains how each are implicated in vaccine candidates likely to be effective and durably protective again COVID-19. | Continue reading
This case series describes severe acute respiratory syndrome coronavirus (SARS-CoV-2) transmission on a international commercial airline flight. | Continue reading
This case series examines the clinical outcomes for young adults hospitalized with COVID-19. | Continue reading
In 1978, Casscells et al1 published a small but important study showing that the majority of physicians, house officers, and students overestimated the positive predictive value (PPV) of a laboratory test result using prevalence and false positive rate. Today, interpretation of d … | Continue reading
This cohort study examines the potential for airborne spread of COVID-19 through investigation of an outbreak among bus riders in Eastern China. | Continue reading
This case report describes clinicopathologic and ultrastructural postmortem findings observed in the olfactory system of 2 patients with SARS-CoV-2. | Continue reading
This nationally representative cohort study assesses whether exposure to the ubiquitous chemical bisphenol A is associated with long-term risk of mortality from cardiovascular disease, cancer, or all causes among US adults. | Continue reading
This analytic modeling study defines the screening performance standards for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) tests that would permit the safe return of students to US residential college campuses for the fall 2020 semester. | Continue reading
Multiple data sets now confirm the increased risk for morbid and mortal complications due to coronavirus disease 2019 (COVID-19) in individuals with preexisting cardiovascular diseases including hypertension, coronary artery disease, and heart failure.1,2 These salient observatio … | Continue reading
This cohort study evaluates the presence of myocardial injury in unselected patients recently recovered from coronavirus disease 2019 (COVID-19). | Continue reading
This case series describes rare putative X-chromosomal loss-of-function variants associated with impaired peripheral mononuclear blood cell interferon signaling in 4 young male patients hospitalized with severe coronavirus disease 2019 (COVID-19) in the Netherlands. | Continue reading
This cross-sectional study combines data from satellites and the National Comorbidity Survey–Adolescent Supplement to measure the association of outdoor artificial light at night with self-reported sleep duration and past-year anxiety and mood disorders in adolescents. | Continue reading
This cross-sectional study estimates the prevalence of severe acute respiratory syndrome coronavirus 2 antibodies in convenience samples from 10 geographic sites in the United States. | Continue reading
To provide evidence for public health recommendations regarding dietary modifications in choice of protein sources that may promote long-term health outcomes, this cohort study assesses overall mortality and cause-specific mortality associated with consumption of plant protein an … | Continue reading
This randomized clinical trial assesses the systemic absorption and pharmacokinetics of the 6 active ingredients (avobenzone, oxybenzone, octocrylene, homosalate, octisalate, and octinoxate) in lotion, aerosol spray, nonaerosol spray, and pump spray sunscreen products under singl … | Continue reading
In this issue of JAMA, Wang et al present evidence that universal masking of health care workers (HCWs) and patients can help reduce transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.1 In the largest health care system in Massachusetts with m … | Continue reading
This Viewpoint uses the example of rapid changes to public reporting on the efficacy of hydroxychloroquine and remdesivir for COVID-19 to illustrate how misinformation damages the public’s trust in science and medicine, and urges accuracy and circumspection in news reports of dev … | Continue reading
This case series describes COVID-19 symptoms persisting a mean of 60 days after onset among Italian patients previously discharged from COVID-19 hospitalization. | Continue reading
This observational study uses NCHS data to evaluate weekly changes in US deaths due to any cause and deaths due to pneumonia, influenza, or COVID-19, by state, from March 1 through May 30, 2020. | Continue reading
This decision analytical model study examines the feasibility of using pool testing to identify patients with coronavirus disease 2019 (COVID-19) in a setting with limited testing availability. | Continue reading
This cohort study examines the association between physical activity and mortality in patients middle aged and older with cancer. | Continue reading
This study compares angiotensin-converting enzyme 2 (ACE2) gene expression, which has been associated with SARS-CoV-2 cell entry, in the nasal epithelium of children vs adults. | Continue reading
This population epidemiology study investigates the prevalence of IgG and IgM antibodies to SARS-CoV-2 in Los Angeles County, California, as a marker of both active and past infections. | Continue reading
In this narrative medicine essay, a pediatric psychiatrist relates how her younger sister with Down syndrome and congenital heart disease has lived well beyond expectation inspired her to help children cultivate hope through love and resilience. | Continue reading
This cohort study examines the association of first childbirth by cesarean vs vaginal delivery with rates of subsequent conceptions and live births among US women. | Continue reading
This study examines associations between use of hydroxychloroquine, azithromycin, or both and in-hospital mortality, ECG changes, and cardiac arrest among patients with COVID-19 hospitalized in the metropolitan New York area in March 2020. | Continue reading
This cohort study assesses the association of frequent religious service attendance with deaths related to drugs, alcohol, and suicide (referred to as deaths from despair) among US health care professionals. | Continue reading
This Viewpoint discusses the 2 most common categories of testing to diagnose SARS-CoV-2—real-time PCR to identify viral RNA and serological diagnosis of IgG and IgM antibodies to assess immune response—and estimates time intervals for test positivity by specimen source to help cl … | Continue reading
This study delineates the transmission dynamics of coronavirus disease 2019 (COVID-19) and evaluates the transmission risk at different exposure window periods before and after symptom onset. | Continue reading
This randomized clinical trial evaluates the safety and efficacy of 2 chloroquine diphosphate dosages in patients with severe coronavirus disease 2019 (COVID-19). | Continue reading
This case series describes clinical characteristics, health services use, and outcomes of patients with confirmed coronavirus disease 2019 (COVID-19) cared for at 12 hospitals of a single health system in the New York City (NYC) area. | Continue reading
This cohort study examines the association of paternal and maternal preconception urinary concentrations of biomarkers of phthalates and phthalate substitutes with singleton preterm birth. | Continue reading
This population-based cohort study assesses the association of preeclampsia with adverse neurodevelopmental outcomes in term births in Norway. | Continue reading
This study uses National Health and Nutrition Examination Survey data to examine the dose-response relationships between step count (steps/d) and step intensity (steps/min) and mortality in a representative sample of US adults aged 40 years or older. | Continue reading
This cross-sectional study seeks to determine which brain changes, including changes in amyloid deposition, gray matter volume, perfusion, and glucose metabolism, are associated with the presence of sleep-disordered breathing in older individuals who are cognitively unimpaired. | Continue reading
In this issue of JAMA, Shen et al report findings from a preliminary study of 5 severely ill patients with coronavirus disease 2019 (COVID-19) who were treated in the Shenzhen Third People's Hospital, China, using plasma from recovered individuals.1 All patients had severe respir … | Continue reading
This case series study evaluates the association of underlying cardiovascular disease and myocardial injury on fatal outcomes in patients with coronavirus disease 2019 (COVID-19). | Continue reading
This case series describes clinical outcomes in 5 Chinese patients with laboratory-confirmed COVID-19, ARDS, and high viral loads despite antiviral treatment who were given human plasma with SARS-CoV-2 antibodies obtained from previously infected and recovered patients. | Continue reading
This JAMA Insights Clinical Update discusses the need to better understand the dynamics of respiratory disease transmission by better characterizing transmission routes, the role of patient physiology in shaping them, and best approaches for source control in the context of the C … | Continue reading
This cohort study examines whether myocardial neuropeptide Y levels in coronary sinus blood samples are associated with outcomes in patients with stable chronic heart failure. | Continue reading
This Viewpoint describes the organization of a regional ICU network in Lombardy, Italy, to handle the surge in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) who require intensive care and uses demand experience in the first 2 weeks of the out … | Continue reading
This Viewpoint explains the technical and regulatory challenges that hampered diagnostic testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the early spread of infection in the US and considers the unintended consequences of making testing more widely … | Continue reading
This Viewpoint describes the outbreak response infrastructure developed by the Taiwanese government following the SARS epidemic in 2003 and actions in response to COVID-19, including dedicated hotlines for symptom reporting, mobile phone messaging and case tracking, and the rampi … | Continue reading
This Viewpoint characterizes reasons for the lack of evidence about the health effects of probiotic supplements and cautions against a “can’t hurt, can’t help” presumption made by consumers and clinicians. | Continue reading
This study uses data from annual financial reports to compare the profitability of large pharmaceutical companies vs other large companies in the S&P 500 Index from 2000 to 2018, measured via gross profit; earnings before interest, taxes, depreciation, and amortization; and n … | Continue reading
This case series describes reverse transcriptase–polymerase chain reaction (RT-PCR) test results in 4 health professionals discharged from hospitalization or quarantine after 2 negative RT-PCR test results and resolution of clinical COVID-19 infection. | Continue reading
This cluster randomized clinical trial compares the effect of N95 respirators vs medical masks worn by health care personnel for prevention of workplace-acquired influenza and other viral respiratory infections in geographically diverse, high-exposure outpatient settings. | Continue reading
This 2020 Recommendation Statement from the US Preventive Services Task Force concludes that current evidence is insufficient to assess the balance of benefits and harms of screening for cognitive impairment in adults 65 years or older (I statement). | Continue reading