Agonist antibody to guanylate cyclase receptor NPR1 regulates vascular tone

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07903-1 Durable agonism of NPR1 achieved with a novel investigational monoclonal antibody could mirror the positive hemodynamic changes in blood pressure and heart failure identified in humans with lifelong expos … | Continue reading


@nature.com | 1 month ago

A brain-to-gut signal controls intestinal fat absorption

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07929-5 Neurons in the dorsal motor nucleus of vagus are involved in the absorption of fat in the intestine, and the natural compound puerarin shows utility in modulating this brain–gut axis to reduce fat absorpt … | Continue reading


@nature.com | 1 month ago

Controllable p- and n-type behaviours in emissive perovskite semiconductors

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07792-4 The charge carrier polarity and concentrations in an emissive perovskite semiconductor can be adjusted by incorporating a molecular dopant widely used for the passivation and structural control of optoele … | Continue reading


@nature.com | 1 month ago

The ultra-high affinity transport proteins of ubiquitous marine bacteria

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07924-w Genome-wide characterization of solute-binding proteins in SAR11, a group of ubiquitous marine bacteria, reveals that they generally combine high binding affinities with narrow binding specificities, sugg … | Continue reading


@nature.com | 1 month ago

Cooling positronium to ultralow velocities with a chirped laser pulse train

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07912-0 The one-dimensional laser cooling of positronium enables testing of quantum electrodynamics and could realize Bose–Einstein condensation in positronium. | Continue reading


@nature.com | 1 month ago

Extreme solar storms and the quest for exact dating with radiocarbon

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07679-4 Understanding how extreme solar storms affect radiocarbon dating has made it possible to obtain calendar ages with annual precision, and future studies could yield insights into archaeology, solar physics … | Continue reading


@nature.com | 1 month ago

Axon-like active signal transmission

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07921-z A method using semi-stable edge of chaos in LaCoO3 enables continuous signal amplification in metallic conductors without separate amplifiers, potentially revolutionizing electronic chip design. | Continue reading


@nature.com | 1 month ago

Drosophila are hosts to the first described parasitoid wasp of adult flies

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07919-7 A study reports the discovery of a parasitoid wasp species that uses the adult stage of Drosophila fruit flies as its host. | Continue reading


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Ancient Rapanui genomes reveal resilience and pre-European contact with the Americas

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07881-4 An analysis of 15 ancient genomes from individuals dating to AD 1670–1950 from Rapa Nui (also known as Easter Island) addresses questions about the population history of the island. | Continue reading


@nature.com | 1 month ago

Decoding drivers of carbon flux attenuation in the oceanic biological pump

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07850-x In situ experimental findings from six contrasting oceanic regimes, at multiple mesopelagic depths, are used to determine the mechanisms that drive microbially mediated carbon flux attenuation in the ocea … | Continue reading


@nature.com | 1 month ago

Multi-pass, single-molecule nanopore reading of long protein strands

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07935-7 A technique for threading long protein strands through a nanopore by electrophoresis and back using a protein unfoldase motor, ClpX, enables single protein molecules to be analyzed multiple times with sin … | Continue reading


@nature.com | 1 month ago

Linear symmetric self-selecting 14-bit kinetic molecular memristors

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07902-2 Harnessing precise molecular kinetics, a 14-bit, energy-efficient dot product engine is realized that unlocks neuromorphic hardware’s potential for core computations. | Continue reading


@nature.com | 1 month ago

Molecular programs guiding arealization of descending cortical pathways

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07895-y Using cross-areal mapping of axonal projections in the mouse neocortex, we identify the subtype-specific developmental dynamics of extratelencephalic neurons and show the functional transcriptional progra … | Continue reading


@nature.com | 1 month ago

Mechanism of BRCA1–BARD1 function in DNA end resection and DNA protection

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07909-9 BRCA1–BARD1 directly promotes double-strand break repair by stimulating long-range DNA end resection pathways. | Continue reading


@nature.com | 1 month ago

Two-axis twisting using Floquet-engineered XYZ spin models with polar molecules

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07883-2 A study demonstrates the application of Floquet Hamiltonian engineering to ultracold trapped polar molecules to realize interactions relevant to quantum metrology and many-body physics. | Continue reading


@nature.com | 1 month ago

Two-dimensional-lattice-confined single-molecule-like aggregates

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07925-9 A molecular aggregate formed in a two-dimensional organic–inorganic hybrid perovskite superlattice with a near-equilibrium distance is shown to have a near-unity photoluminescence quantum yield like that … | Continue reading


@nature.com | 1 month ago

One month convection timescale on the surface of a giant evolved star

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-07836-9 Presenting a series of interferometric images of R Doradus, this study reveals prominent convective structures on the surface of this giant evolved star that have a timescale of about one month. | Continue reading


@nature.com | 1 month ago

Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-08024-5 Heteromeric amyloid filaments of ANXA11 and TDP-43 in FTLD-TDP Type C | Continue reading


@nature.com | 1 month ago

Structure of human TIP60-C histone exchange and acetyltransferase complex

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-08011-w Structure of human TIP60-C histone exchange and acetyltransferase complex | Continue reading


@nature.com | 1 month ago

Gasdermin D-mediated metabolic crosstalk promotes tissue repair

Nature, Published online: 11 September 2024; doi:10.1038/s41586-024-08022-7 Gasdermin D-mediated metabolic crosstalk promotes tissue repair | Continue reading


@nature.com | 1 month ago

Cracking the tubulin code: enzyme structures offer clues to microtubule control

Nature, Published online: 11 September 2024; doi:10.1038/d41586-024-02822-7 Cellular structural filaments called microtubules are made up of units of tubulin proteins. Various enzymes add modifications to and remove them from tubulin units; together, these modifications form a ‘t … | Continue reading


@nature.com | 1 month ago

Cell-to-cell tunnels rescue neurons from degeneration

Nature, Published online: 11 September 2024; doi:10.1038/d41586-024-02862-z Tiny cellular tubes between neurons and brain cells called microglia serve as conduits for the export of toxic protein aggregates from neurons and the import of healthy organelles, keeping neurodegenerati … | Continue reading


@nature.com | 1 month ago

Why does heart disease affect so many young South Asians?

Nature, Published online: 11 September 2024; doi:10.1038/d41586-024-02916-2 Geneticists are trying to understand the elevated risks of heart and metabolic disease among people of South Asian ancestry, but some question whether a purely biological approach is best. | Continue reading


@nature.com | 1 month ago

Lipid recycling by macrophage cells drives the growth of brain cancer

Nature, Published online: 11 September 2024; doi:10.1038/d41586-024-02868-7 In brain tumours, immune cells called macrophages scavenge lipid debris from the myelin sheath of neurons. These lipid-laden macrophages cause immunosuppression, and their transfer of lipids to tumours fu … | Continue reading


@nature.com | 1 month ago

Human embryo models are getting more realistic — raising ethical questions

Nature, Published online: 11 September 2024; doi:10.1038/d41586-024-02915-3 Dozens of labs around the world are striving to grow models of human embryos to study development, fertility and therapies. They are entering uncharted ethical territory. | Continue reading


@nature.com | 1 month ago

Why some women enter menopause early — and how that could affect their cancer risk

Nature, Published online: 11 September 2024; doi:10.1038/d41586-024-02905-5 Genomic analysis reveals a host of genetic variants that affect how quickly fertility ends, among them one that reduces reproductive span by six years. | Continue reading


@nature.com | 1 month ago

The grassroots organizations continuing the fight for Ukrainian science

Nature, Published online: 11 September 2024; doi:10.1038/d41586-024-02957-7 More than two years after Russia invaded Ukraine, initiatives supporting Ukrainian researchers are counting the long-term career costs of the conflict. | Continue reading


@nature.com | 1 month ago

US and China inch towards renewing science-cooperation pact — despite tensions

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02782-y Sources say the nations are close to a deal, but the looming US presidential election is likely bogging it down. | Continue reading


@nature.com | 1 month ago

Europe sidelines Alzheimer’s drug: lessons must be learnt

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02914-4 If the European Medicines Agency takes an overly cautious approach to selecting specialists to advise on new medicines, people could be left without treatments. | Continue reading


@nature.com | 1 month ago

Data on SDGs are riddled with gaps. Citizens can help

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02920-6 The UN wants to put communities at the heart of its data-collection efforts in support of the Sustainable Development Goals. Now governments must step up. | Continue reading


@nature.com | 1 month ago

How to support Indigenous Peoples on biodiversity: be rigorous with data

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02913-5 Questions surrounding an often-repeated statistic about Indigenous Peoples and biodiversity show that researchers should take more care when sourcing facts. | Continue reading


@nature.com | 1 month ago

NASA okays mission to search for life on Jupiter’s moon Europa

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02939-9 After resolving a threat to the spacecraft’s circuitry, the US space agency is now weeks away from launching the orbiter. | Continue reading


@nature.com | 1 month ago

Mpox: apply COVID lessons to control outbreak in Africa

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02912-6 As mpox becomes a global health emergency, global health leaders must better coordinate their plans and pharmaceutical companies must be prepared to make vaccines affordable. | Continue reading


@nature.com | 1 month ago

How a struggling biotech company became a university ‘spin-in’

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02627-8 Despite meeting a clinical and societal need for snakebite antivenom development, VenomAb folded after four years, propelling co-founder Andreas Laustsen-Kiel to a role that combines entrepreneurship and … | Continue reading


@nature.com | 1 month ago

The pharmaceutical industry must embrace synthetic alternatives to horseshoe-crab blood

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02893-6 The pharmaceutical industry must embrace synthetic alternatives to horseshoe-crab blood | Continue reading


@nature.com | 1 month ago

Back to the future: two books that tried to predict how science would evolve

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02669-y Authors in the 1920s and 1970s had different takes on how science would shape the future. Nature’s reviewers had similarly diverse views on how accurate these predictions would be. | Continue reading


@nature.com | 1 month ago

Update regulator guidance to show that animal research really is no longer king

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02895-4 Update regulator guidance to show that animal research really is no longer king | Continue reading


@nature.com | 1 month ago

Artificial intelligence can help to make animal research redundant

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02894-5 Artificial intelligence can help to make animal research redundant | Continue reading


@nature.com | 1 month ago

Energy storage overcapacity can cause power system instability and blackouts, too

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02896-3 Energy storage overcapacity can cause power system instability and blackouts, too | Continue reading


@nature.com | 1 month ago

Stereospecific radical coupling with a non-natural photodecarboxylase

Nature, Published online: 10 September 2024; doi:10.1038/s41586-024-08004-9 Stereospecific radical coupling with a non-natural photodecarboxylase | Continue reading


@nature.com | 1 month ago

Publisher Correction: Precision spectroscopy on 9Be overcomes limitations from nuclear structure

Nature, Published online: 10 September 2024; doi:10.1038/s41586-024-08018-3 Publisher Correction: Precision spectroscopy on 9Be overcomes limitations from nuclear structure | Continue reading


@nature.com | 1 month ago

Daily briefing: Meet the recipient of the first whole-eye transplant

Nature, Published online: 10 September 2024; doi:10.1038/d41586-024-02959-5 The world’s first successful face transplant including a whole eye, the US and China inch towards renewing a science-cooperation pact and how ‘likes’ fuel a spiral of misinformation. | Continue reading


@nature.com | 1 month ago

Daily briefing: What we learnt at The Centre for Unusual Collaborations

Nature, Published online: 09 September 2024; doi:10.1038/d41586-024-02953-x Scientists come together for unexpected discoveries and ‘collateral happiness’. Plus, ways to persuade a climate sceptic and how the brain knows whether you should cough or sneeze. | Continue reading


@nature.com | 1 month ago

World’s first whole-eye transplant: the innovations that made it possible

Nature, Published online: 09 September 2024; doi:10.1038/d41586-024-02906-4 The first face transplant to also include an eyeball was a surgical coup — but restoring vision remains a challenge. | Continue reading


@nature.com | 1 month ago

Eggs from older mice regain youth when grown in young cells

Nature, Published online: 09 September 2024; doi:10.1038/d41586-024-02872-x Rejuvenated eggs were more likely to result in healthy offspring. | Continue reading


@nature.com | 1 month ago

Publisher Correction: Krause corpuscles are genital vibrotactile sensors for sexual behaviours

Nature, Published online: 09 September 2024; doi:10.1038/s41586-024-08014-7 Publisher Correction: Krause corpuscles are genital vibrotactile sensors for sexual behaviours | Continue reading


@nature.com | 1 month ago

How influencers and algorithms mobilize propaganda — and distort reality

Nature, Published online: 09 September 2024; doi:10.1038/d41586-024-02917-1 The engagement-fuelled logic of social media has bequeathed us a world in which what’s trending is a yardstick for what’s true. | Continue reading


@nature.com | 1 month ago

Wildfires are spreading fast in Canada — we must strengthen forests for the future

Nature, Published online: 09 September 2024; doi:10.1038/d41586-024-02919-z As wildfires become more frequent and severe, efforts to improve the resilience of forests must be grounded in data and led by Indigenous Peoples. | Continue reading


@nature.com | 1 month ago