How stress can disrupt memory and lead to anxiety

Nature, Published online: 15 November 2024; doi:10.1038/d41586-024-03724-4 In mice, stress altered the way that the brain packaged memories, resulting in an unnecessary fear response — but drugs were able to reverse the effect. | Continue reading


@nature.com | 2 months ago

Major biomedical funder NIH poised for massive reform under Trump 2.0

Nature, Published online: 15 November 2024; doi:10.1038/d41586-024-03736-0 Sweeping changes and more research scrutiny could be on the way for the US National Institutes of Health. | Continue reading


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How human brains got so big: our cells learned to handle the stress that comes with size

Nature, Published online: 15 November 2024; doi:10.1038/d41586-024-03716-4 Understanding how human neurons cope with the energy demands of a large, active brain could open up new avenues for treating neurological disorders. | Continue reading


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Fragments of eternal youth

Nature, Published online: 15 November 2024; doi:10.1038/d41586-024-03731-5 Divided loyalties. | Continue reading


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Radiation for dummies: the female mannequins testing space-travel safety

Nature, Published online: 15 November 2024; doi:10.1038/d41586-024-03744-0 The female figures, dubbed Helga and Zohar, took a trip round the moon to measure the levels of space radiation outside low Earth orbit. | Continue reading


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Daily briefing: Tech giants invest in next-generation geothermal energy

Nature, Published online: 15 November 2024; doi:10.1038/d41586-024-03776-6 We explore efforts to tap the Earth for its heat energy. Plus, trust in scientists is slowly recovering in the United States | Continue reading


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Lunar farside volcanism 2.8 billion years ago from Chang’e-6 basalts

Nature, Published online: 15 November 2024; doi:10.1038/s41586-024-08382-0 Lunar farside volcanism 2.8 billion years ago from Chang’e-6 basalts | Continue reading


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Trust in scientists starts to recover in the United States at last — but barely

Nature, Published online: 14 November 2024; doi:10.1038/d41586-024-03723-5 Confidence that scientists will make decisions in the public interest nosedived at the onset of the pandemic but has now started to rise. | Continue reading


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Geothermal power is vying to be a major player in the world’s clean-energy future

Nature, Published online: 14 November 2024; doi:10.1038/d41586-024-03621-w With technical advances and enthusiasm from policymakers, advocates say the time for next-generation geothermal has come. | Continue reading


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Engineered receptors for soluble cellular communication and disease sensing

Nature, Published online: 14 November 2024; doi:10.1038/s41586-024-08366-0 Engineered receptors for soluble cellular communication and disease sensing | Continue reading


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Daily briefing: Big tomatoes get sweeter thanks to CRISPR editing

Nature, Published online: 14 November 2024; doi:10.1038/d41586-024-03748-w A genetic tweak can make big tomatoes much sweeter. Plus, how smartphone signals can help map the upper atmosphere | Continue reading


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Why AI-generated recommendation letters sell applicants short

Nature, Published online: 14 November 2024; doi:10.1038/d41586-024-03481-4 ChatGPT can do many things, but writing a personal endorsement is not one of them, says Maroun Khoury. | Continue reading


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Huge carnivorous ‘terror bird’ rivalled the giant panda in size

Nature, Published online: 14 November 2024; doi:10.1038/d41586-024-03670-1 Newly analysed fossil came from what could be the biggest-known member of a family of apex avian predators. | Continue reading


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Can robotic lab assistants speed up your work?

Nature, Published online: 14 November 2024; doi:10.1038/d41586-024-03714-6 When it comes to laboratory automation, small and simple is the winning combination. | Continue reading


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Resistance to crucial malaria drug detected in severely ill kids in Africa

Nature, Published online: 14 November 2024; doi:10.1038/d41586-024-03672-z The development worries researchers because children are particularly vulnerable to the disease. | Continue reading


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Keeping the global consumption within the planetary boundaries

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08154-w An analysis of the environmental footprints of consumption finds that planetary boundary transgressions can be mitigated by following an effective mitigation pathway focused on the food and services sector … | Continue reading


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Adult skull bone marrow is an expanding and resilient haematopoietic reservoir

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08163-9 Skull bone marrow expands during adult life, exhibits lifelong vascular growth and increases its haematopoietic potential during ageing. | Continue reading


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Structural variation in the pangenome of wild and domesticated barley

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08187-1 A pangenome analysis of 76 wild and domesticated barley accessions in combination with short-read sequence data of 1,315 barley genotypes indicates that allelic diversity at structurally complex loci may h … | Continue reading


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Migrating is not enough for modern planktonic foraminifera in a changing ocean

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08191-5 Low-latitude planktonic foraminifera are coping with rapid ocean warming, acidification and nutrient shifts by migrating to deeper water-column depths or polewards, displacing higher-latitude species and r … | Continue reading


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Past foraminiferal acclimatization capacity is limited during future warming

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08029-0 Data from the fossil record, together with computational modelling, are used to assess the response of foraminifera (marine zooplankton) to temperature changes through time and to predict how well they wil … | Continue reading


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Entanglement and iSWAP gate between molecular qubits

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08177-3 Intrinsic molecular resources are used to implement a two-qubit iSWAP gate using individually trapped X1Σ+ NaCs molecules. | Continue reading


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A combinatorial neural code for long-term motor memory

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08193-3 Long-term tracking of learned actions in mouse motor cortex shows that learned actions are retained with their context, and learning new tasks creates new memories, which do not overwrite or modify existin … | Continue reading


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Biodiversity impacts of the 2019–2020 Australian megafires

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08174-6 Data collected from more than 2,000 taxa provide an unparalleled opportunity to quantify how extreme wildfires affect biodiversity, revealing that the largest effects on plants and animals were in areas wi … | Continue reading


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Releasing a sugar brake generates sweeter tomato without yield penalty

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08186-2 A study identifies two genes that act as brakes controlling the sugar content of tomatoes and demonstrates their manipulation to generate sweeter tomatoes without affecting the fruit size and yield. | Continue reading


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Intravenous and intracranial GD2-CAR T cells for H3K27M+ diffuse midline gliomas

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08171-9 We evaluated the use of chimeric antigen receptor-modified T cells targeting GD2 (GD2-CART) for H3K27M+ diffuse midline glioma (DMG), finding that intravenous administration of GD2-CART, followed by intrac … | Continue reading


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Read–write mechanisms of H2A ubiquitination by Polycomb repressive complex 1

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08183-5 Cryo-electron microscopy and biochemical studies elucidate the read–write mechanisms of non-canonical PRC1-containing RYBP in histone H2A lysine 119 monoubiquitination and their roles in maintaining epigen … | Continue reading


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Observation of Hilbert space fragmentation and fractonic excitations in 2D

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08188-0 Using quantum gas microscopy, Hilbert space fragmentation and fractonic excitations are observed in a two-dimensional tilted Bose–Hubbard model. | Continue reading


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Prefrontal transthalamic uncertainty processing drives flexible switching

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08180-8 By examining neural responses from tree shrews performing hierarchical decision tasks with rule reversals, the authors identify a thalamocortical mechanism for regulating cognitive flexibility. | Continue reading


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Foundation models for fast, label-free detection of glioma infiltration

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08169-3 FastGlioma is a visual foundation model for fast and accurate detection of glioma infiltration in fresh, unprocessed surgical tissue. | Continue reading


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Clinical functional proteomics of intercellular signalling in pancreatic cancer

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08225-y TMEPro profiles the glycosylated secreted and plasma membrane proteome of 100 human pancreatic tissue samples, defines cell type origins and identifies potential paracrine cross-talk mediated through tyros … | Continue reading


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Photochemical permutation of thiazoles, isothiazoles and other azoles

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08342-8 Photochemical permutation of thiazoles, isothiazoles and other azoles | Continue reading


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Dental evidence for extended growth in early Homo from Dmanisi

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08205-2 Fossil tooth development suggests an extended human growth phase occurred at least 1.77 million years ago, possibly reflecting a shift towards extended parenting and reproductive success, rather than incre … | Continue reading


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NK2R control of energy expenditure and feeding to treat metabolic diseases

Nature, Published online: 13 November 2024; doi:10.1038/s41586-024-08207-0 In mouse and nonhuman primate models, treatment with selective, long-acting neurokinin 2 receptor agonists aids weight loss by suppressing appetite and increasing energy expenditure, as well as by increasi … | Continue reading


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How AI is reshaping science and society

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03679-6 Artificial-intelligence tools such as ChatGPT might soon become fully autonomous by learning to perceive and interact with their environment. | Continue reading


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Postdocs count the cost of living in Ireland’s capital

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03608-7 Female researchers and those from outside the European Union are paying a particularly heavy price to live in Dublin. | Continue reading


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Can AI review the scientific literature — and figure out what it all means?

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03676-9 Artificial intelligence could help speedily summarize research. But it comes with risks. | Continue reading


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Thixotropic world

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03685-8 A question of perspective. | Continue reading


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Australian megafires drove complex biodiversity outcomes

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03549-1 An ambitious analysis of data has revealed the effects of the 2019–20 Australian megafires on biodiversity. It turns out that the outcome is more nuanced than just the anticipated picture of a massive loss … | Continue reading


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Iron levels unexpectedly limit bacterial growth in the ocean’s twilight zone

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03697-4 Microbial growth at depths of 200–500 metres has been found to be limited by iron, a key micronutrient. To meet their iron requirement, bacteria inhabiting the twilight zone manufacture siderophores — mole … | Continue reading


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Robotic exoskeleton adapts to changes in leg movements in real time

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03546-4 Wearable robots that assist leg movements could transform the lives of people with reduced mobility — but only if the devices can adapt in real time to support a vast range of human activities. Machine lea … | Continue reading


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Fossilized bird skull from 80 million years ago clarifies early avian evolution

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03694-7 Key aspects of early bird evolution have been difficult to resolve, owing to a lack of suitably preserved fossilized remains. A fossilized skull of a bird that lived during the age of the dinosaurs helps t … | Continue reading


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Two for one: candidate obesity drug boosts energy use and curbs calorie intake

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03548-2 The discovery of a pathway that controls appetite and calorie burning has led to the development of a drug that modulates both by targeting one receptor, offering a promising strategy for weight loss and i … | Continue reading


@nature.com | 2 months ago

Tomato engineering hits the sweet spot to make big sugar-rich fruit

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03302-8 A genetic regulator of tomato sweetness has been identified through comparison of wild and domesticated varieties of the plant. Genetically engineering tomatoes to alter this gene increases sugar content w … | Continue reading


@nature.com | 2 months ago

Errors in cell division stopped by an atypical cyclin-dependent kinase

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03691-w The enzyme cyclin-dependent kinase 1 (CDK1) and its partner cyclin B1 were thought to be sufficient to achieve error-free cell division. But now CDK5, an atypical cyclin-dependent kinase mostly known for i … | Continue reading


@nature.com | 2 months ago

Are rising carbon dioxide and nitrogen deposition a joint threat to biodiversity globally?

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03663-0 Whether rising carbon dioxide concentrations affect terrestrial species diversity around the globe is, surprisingly, almost unstudied. A 24-year field experiment shows that adding nitrogen to grassland plo … | Continue reading


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Space weather mapped by millions of smartphones

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03545-5 Phone users around the world are enabling the creation of a space-weather monitor that will deepen our understanding of the physics governing Earth’s ionized upper atmosphere and improve the accuracy of sa … | Continue reading


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What happens when a bacterium gets into a fungus and stays — for generations

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03700-y Bacteria living inside other cells can form stable, mutually beneficial partnerships with their hosts, but it is rare that two organisms are sufficiently compatible on their first encounter. Injecting bact … | Continue reading


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Growing up slowed down for an early Homo individual

Nature, Published online: 13 November 2024; doi:10.1038/d41586-024-03547-3 Human children pair fast growth of a large brain with slow body growth. Ancient Homo fossil teeth reveal that hominin dental growth rates began to slow before there was a major increase in brain size compa … | Continue reading


@nature.com | 2 months ago