A quantitative analysis of human encroachment into wildlife habitats highlights that horseshoe bats occur in hotspots of forest fragmentation, livestock density and human populations—particularly in China—increasing the risk of SARS-related zoonotic pathogen spillover. | Continue reading
SARS-CoV-2 variants have accumulated multiple defining mutations within their spike glycoproteins. Here, the authors report a structural basis for broad neutralization of several variants by a heavy chain antibody fragment and provide a mutational analysis focusing on antibody ev … | Continue reading
An integrated analysis of de novo and inherited coding variants in 42,607 individuals with autism spectrum disorder identifies 60 risk genes of which five have not previously been associated with neurodevelopmental disorders. | Continue reading
Calorie availability and extent of food shortages for each nation are estimated following regional or global nuclear war, including impacts on major crops, livestock and fishery production. | Continue reading
On the 70th anniversary of Alan Turing’s seminal paper on morphogenesis, we look back at the history of the paper and its many applications. | Continue reading
Retro-Cascorder, a system for time-ordered recording of transcriptional output, uses retrons as a tag to mediate DNA barcode acquisition in a CRISPR array. | Continue reading
A bioengineered cornea made of collagen restores vision in a pilot clinical study. | Continue reading
Although Jonathan Pruitt, the researcher at the centre of a retractions scandal, has resigned, former lab members and collaborators continue dealing with the fallout. | Continue reading
The simulation of quantum dynamics is a challenging task to solve with classical resources. An experiment with a trapped-ion quantum processor now shows the efficient simulation of the evolution of large-scale many-body quantum systems. | Continue reading
Heatwaves, droughts, floods and storms push up the number of cases, make diseases more severe and hamper people’s ability to cope. | Continue reading
The henipavirus can cause respiratory symptoms and is related to Nipah and Hendra viruses, but cannot spread easily in people. | Continue reading
Over the past four decades, Arctic Amplification - the ratio of Arctic to global warming - has been much stronger than thought, and is probably underestimated in climate models, suggest analyses of observations and the CMIP5 and CMIP6 simulations. | Continue reading
Difficult tasks can lead to build-up of a signalling molecule in the brain, triggering fatigue. | Continue reading
Difficult tasks can lead to build-up of a signalling molecule in the brain, triggering fatigue. | Continue reading
Antarctic sample dated at 3–5 million years old extracted as international ice-drilling teams race to extend Earth’s climate record. | Continue reading
Experiments show that swimming starfish embryos spontaneously assemble into large chiral crystals that exhibit self-sustained chiral oscillations and unconventional deformation responses characteristic of odd elastic materials. | Continue reading
Researchers at Newcastle University have discovered a mechanism by which earthquakes create bursts of hydrogen peroxide and oxygen in hot underground fractures. These may have played a vital role in the early evolution and origin of life on Earth. | Continue reading
Advances in 3D neuronal cultures have allowed unprecedented access to the mechanisms underlying brain diseases. This work describes the novel Modular Neuronal Network (MoNNet) system, which enables more complex studies of cortical neuronal ensemble dynamics. | Continue reading
More settlements will suffer as heavy rains and unregulated construction destabilize slopes in the tropics, models show. | Continue reading
Cnidarians and ctenophores have morphologically simpler nervous systems than those of bilaterians. Discovery and characterization of neuropeptides in a comb jelly and a sea anemone support a common origin of animal peptidergic neurons from digestive cells that could sense their e … | Continue reading
A systematic review shows that >58% of infectious diseases confronted by humanity, via 1,006 unique pathways, have at some point been affected by climatic hazards sensitive to GHGs. These results highlight the mounting challenge for adaption and the urgent need to reduce GHG emis … | Continue reading
Systematic measurements of the interactions between proteins found on the surfaces of human leukocytes provides a global view of the way that immune cells are dynamically connected by receptors. | Continue reading
Researchers demonstrate low-threshold multiple exciton generation and photocurrent quantum efficiency exceeding 100% from high-energy photons in perovskite nanocrystals. | Continue reading
Quantitative polymerase chain reaction allows the real-time detection of nucleic acids in human samples, representing a gold standard for infection detection, but it cannot be easily converted into a point-of-care approach. Here a strategy is proposed to leverage plasmonic polyme … | Continue reading
The anniversary of a historic publication provides the chance to reflect on how we consider limits and on the value of cross-fertilization between research traditions. | Continue reading
David Bimler, also known as Smut Clyde, scours the scientific literature for bogus articles. | Continue reading
David Bimler, also known as Smut Clyde, scours the scientific literature for bogus articles. | Continue reading
To make the most of artificial intelligence, data and software must be freely shared, and computational, theoretical and experimental researchers must work together closely. | Continue reading
Procedures used in life support and to preserve organs in deceased human donors might one day need to be re-evaluated in the wake of a study that restored some cell function in pigs one hour after death. | Continue reading
Scientists warn that the findings aren’t yet clinically relevant but say the research raises ethical questions about the definition of death. | Continue reading
Cutting out single-use plastics was the beginning of a sustainability transformation, says Jane Kilcoyne. | Continue reading
Transplanting human cells into animal brains brings insights into development and disease along with new ethical questions. | Continue reading
OrganEx—an extracorporeal pulsatile-perfusion system with cytoprotective perfusate for porcine whole-body settings—preserved tissue integrity, decreased cell death and restored selected molecular and cellular processes across multiple vital organs after 1 h of warm ischaemia in p … | Continue reading
Examination of archaeological pottery residues and modern genes suggest that environmental conditions, subsistence economics and pathogen exposure may explain selection for lactase persistence better than prehistoric consumption of milk. | Continue reading
Some studies suggest that the risk of cardiovascular problems, such as a heart attack or stroke, remains high even many months after a SARS-CoV-2 infection clears up. Researchers are starting to pin down the frequency of these issues and what is causing the damage. | Continue reading
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Niarchou et al. identify 69 genomic loci associated with people’s synchronization to a musical beat. The genetic architecture of beat synchronization was enriched for genes involved in early brain development and lifelong brain function. | Continue reading
Analyses of data on 21 billion friendships from Facebook in the United States reveal associations between social capital and economic mobility. | Continue reading
Yu and colleagues report a modified and flexible Evans-Perkins heat pump cycle integrating heat recovery and storage and demonstrate its application in a prototype heat pump. The recovered heat can be used as an ancillary heat source for the heat pump’s operation and to defrost t … | Continue reading