Build your own receptor: modular system can be tailored to any antigen

Nature, Published online: 20 December 2024; doi:10.1038/d41586-024-04178-4 PAGERs provide modular, customizable G-protein-coupled receptors for cell-signalling studies. | Continue reading


@nature.com | 26 days ago

Can novelty scores on papers shift the power dynamics in scientific publishing?

Nature, Published online: 20 December 2024; doi:10.1038/d41586-024-04021-w By providing measures of novelty, DeSci Publish hopes to shift the bargaining power between journals and authors. | Continue reading


@nature.com | 26 days ago

Is political interference causing faculty brain drain in the southern United States?

Nature, Published online: 20 December 2024; doi:10.1038/d41586-024-04070-1 Faculty members say academic freedom is under fire, and many are seeking work outside the region. | Continue reading


@nature.com | 26 days ago

I create routes through trees to help stop howler monkeys being electrocuted by power lines

Nature, Published online: 20 December 2024; doi:10.1038/d41586-024-04170-y Inés Azofeifa Rojas monitors troop behaviour to maintain canopy connectivity. | Continue reading


@nature.com | 26 days ago

Daily briefing: Explore 2024 with Leif Penguinson

Nature, Published online: 20 December 2024; doi:10.1038/d41586-024-04208-1 Can you spot the penguin in every game this year? | Continue reading


@nature.com | 26 days ago

That Christmas jumper is a marvel of complicated physics

Nature, Published online: 20 December 2024; doi:10.1038/d41586-024-04173-9 Models and experiments demonstrate what happens when a knitted fabric is deformed. | Continue reading


@nature.com | 26 days ago

Behind the scenes of Nature News & Views in 2024

Nature, Published online: 20 December 2024; doi:10.1038/d41586-024-04246-9 From a Death Star moon to gene editing, construction fuses and red mud — we round up some of the highlights of this year’s News & Views section. | Continue reading


@nature.com | 26 days ago

Are you what you eat? How food shapes self-image

Nature, Published online: 19 December 2024; doi:10.1038/d41586-024-04163-x For centuries we’ve linked what we consume to how we feel about ourselves. | Continue reading


@nature.com | 27 days ago

Inside an Argentinian nuclear reactor, science and politics collide

Nature, Published online: 19 December 2024; doi:10.1038/d41586-024-04016-7 At a facility on the outskirts of Buenos Aires, women are fighting budget cuts and inequality in the workplace. | Continue reading


@nature.com | 27 days ago

How to find your place in science through an industry postdoc

Nature, Published online: 19 December 2024; doi:10.1038/d41586-024-04169-5 Three researchers talk about life in companies and the key to unlocking opportunities. | Continue reading


@nature.com | 27 days ago

Daily briefing: Climate scientists determined to rise to the challenge of Trump 2.0

Nature, Published online: 19 December 2024; doi:10.1038/d41586-024-04244-x We investigate how ancient humans ran and hear from climate scientists who are rising to the challenges of an impending Trump presidency. | Continue reading


@nature.com | 27 days ago

Humanity’s noise is the natural world’s enemy

Nature, Published online: 19 December 2024; doi:10.1038/d41586-024-04162-y People have profoundly altered the planet’s soundscape. It’s time to quieten down so that other species can thrive. | Continue reading


@nature.com | 27 days ago

A reinforced lunar dynamo recorded by Chang'e-6 farside basalt

Nature, Published online: 19 December 2024; doi:10.1038/s41586-024-08526-2 A reinforced lunar dynamo recorded by Chang'e-6 farside basalt | Continue reading


@nature.com | 27 days ago

Signatures of ambient pressure superconductivity in thin film La3Ni2O7

Nature, Published online: 19 December 2024; doi:10.1038/s41586-024-08525-3 Signatures of ambient pressure superconductivity in thin film La3Ni2O7 | Continue reading


@nature.com | 27 days ago

Skin in the game — locally made antibodies fight resident bacteria

Nature, Published online: 19 December 2024; doi:10.1038/d41586-024-04205-4 How immune responses arise against microorganisms living on the skin is not fully understood. The discovery that skin maintains its own system to form antibody responses reveals an unexpected vaccination r … | Continue reading


@nature.com | 27 days ago

A blood test detects aged cells

Nature, Published online: 19 December 2024; doi:10.1038/d41586-024-04172-w Proteins could serve as biomarkers for senescent cells, which have stopped dividing but have not yet died. | Continue reading


@nature.com | 27 days ago

How to beat the biases harming women’s mental health

Nature, Published online: 19 December 2024; doi:10.1038/d41586-024-04164-w A commanding examination of the factors that play into women’s mental ill health should prompt soul searching by readers of all stripes. | Continue reading


@nature.com | 27 days ago

Humans evolved for distance running – but ancestor ‘Lucy’ didn’t go far or fast

Nature, Published online: 19 December 2024; doi:10.1038/d41586-024-04194-4 3D models of Australopithecus afarensis suggest the muscular adaptations that made modern humans better runners. | Continue reading


@nature.com | 27 days ago

How car and battery companies can work around US trade tariffs and rules

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04168-6 Understanding China’s and other nations’ responses to US trade measures can help policymakers and firms find ways to manage economic competition. | Continue reading


@nature.com | 28 days ago

Controversial COVID study that promoted unproven treatment retracted after four-year saga

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04014-9 Paper on hydroxychloroquine led by French researcher Didier Raoult is second-most-cited study ever to be withdrawn. | Continue reading


@nature.com | 28 days ago

Moral conundrums and more: Books in brief

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04165-9 Andrew Robinson reviews five of the best science picks. | Continue reading


@nature.com | 28 days ago

How Los Angeles neighbours partnered to show under-represented students the ‘unspoken rules’ to success

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-03983-1 Laurie Barge and Arezoo Khodayari created an internship between NASA’s Jet Propulsion Laboratory and California State University, Los Angeles to launch the careers of students from minority backgrounds. | Continue reading


@nature.com | 28 days ago

What were some of the biggest stories of 2024? Join us for the Nature Podcast quiz!

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04227-y In a fiendish quiz our contestants battle to remember the details of the science stories that made 2024 special. | Continue reading


@nature.com | 28 days ago

This digital-memory device keeps its cool even at 600 °C

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04109-3 A battery-like technology uses a metal called tantalum to create an equivalent of digital 0s and 1s. | Continue reading


@nature.com | 28 days ago

Giant study finds untrustworthy trials pollute gold-standard medical reviews

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04206-3 Two-year collaboration aims to create tools to help counter the tide of flawed research. | Continue reading


@nature.com | 28 days ago

Pioneering journal eLife faces major test after loss of impact factor

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04199-z The open-access title’s bold publishing model has bought long-bubbling conflicts to the fore. | Continue reading


@nature.com | 28 days ago

Sea ice is shrinking during Antarctic winter: here’s what it means for Earth’s oceans and atmosphere

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04078-7 The extent of Antarctic sea ice dropped precipitously in 2023. Analysis shows that this decline has increased the transfer of ocean heat to the atmosphere — in turn affecting ocean circulation and the freq … | Continue reading


@nature.com | 28 days ago

Vapour-deposited thin films raise the possibility of portable nuclear clocks

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04125-3 A rare isotope, thorium-229, exhibits a unique low-energy nuclear transition that could form the basis of a precise nuclear clock. Observation of this transition in vapour-deposited thin films, which requi … | Continue reading


@nature.com | 28 days ago

Machine learning helps to determine the diverse conformations of RNA molecules

Nature, Published online: 18 December 2024; doi:10.1038/d41586-024-04134-2 An innovative technique called HORNET uses atomic force microscopy and a machine-learning architecture called a deep neural network to recapitulate the 3D structures of individual RNA molecules. This metho … | Continue reading


@nature.com | 28 days ago

A dormant overmassive black hole in the early Universe

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08210-5 A dormant supermassive black hole at high redshift that is substantially overmassive relative to its host galaxy has been detected, indicating a much larger population of dormant black holes around the epo … | Continue reading


@nature.com | 28 days ago

Four-component protein nanocages designed by programmed symmetry breaking

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-07814-1 Using viral capsid architectures as template for design, higher triangulation number nanocages that require symmetry breaking offer potential advances in targeted delivery and antigen-displaying vaccines. | Continue reading


@nature.com | 28 days ago

Growth-based monolithic 3D integration of single-crystal 2D semiconductors

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08236-9 Single-crystalline materials can be grown on amorphous surfaces at below 400 °C, enabling monolithic three-dimensional integration of vertically stacked transistors. | Continue reading


@nature.com | 28 days ago

Record-low Antarctic sea ice in 2023 increased ocean heat loss and storms

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08368-y The record-low Antarctic sea-ice decline in 2023 substantially altered Southern Ocean–atmosphere interaction leading to unprecedented wintertime turbulent ocean heat loss to the atmosphere, enhanced stormi … | Continue reading


@nature.com | 28 days ago

Tidally driven remelting around 4.35 billion years ago indicates the Moon is old

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08231-0 Lunar rock and zircon ages were reset by a remelting event driven by the Moon’s orbital evolution, reconciling existing discrepancies in estimates for the formation time of the Moon and the crystallization … | Continue reading


@nature.com | 28 days ago

Synaptic basis of feature selectivity in hippocampal neurons

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08325-9 A temporally asymmetric synaptic plasticity kernel results from bidirectional modifications of synaptic weights around the induction of a place field. | Continue reading


@nature.com | 28 days ago

Determining structures of RNA conformers using AFM and deep neural networks

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-07559-x HORNET, a method that uses unsupervised machine learning and deep neural networks to analyse atomic force microscopy data enables structural determination of RNA molecules in multiple conformations. | Continue reading


@nature.com | 28 days ago

Atmospheric rivers cause warm winters and extreme heat events

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08238-7 Seasons with more frequent atmospheric rivers (ARs) also have warmer than average temperatures in many mid-latitude regions, and AR events are associated with temperature anomalies of 5–10 °C above the cli … | Continue reading


@nature.com | 28 days ago

Engineered extrachromosomal oncogene amplifications promote tumorigenesis

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08318-8 Large extrachromosomal DNAs are engineered using a CRISPR- and Cre–loxP-based approach and shown to drive cancer in mouse models, with potential applications in determining the role of oncogene amplificati … | Continue reading


@nature.com | 28 days ago

Timely TGFβ signalling inhibition induces notochord

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08332-w Through analysis of developing chick embryos and in vitro differentiation of embryonic stem cells, a study develops a method to generate a model of the human trunk with a notochord. | Continue reading


@nature.com | 28 days ago

Hierarchical design of pseudosymmetric protein nanocages

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08360-6 A new computational method for design of pseudosymmetric self-assembling protein nanomaterials has resulted in purification of cage-like protein assemblies containing 960 subunits with a diameter of 96 nm. | Continue reading


@nature.com | 28 days ago

Terahertz field-induced metastable magnetization near criticality in FePS3

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08226-x Intense terahertz pulses are used to induce metastable magnetization with a remarkably long lifetime of more than 2.5 milliseconds in a van der Waals antiferromagnet, FePS3. | Continue reading


@nature.com | 28 days ago

Spatial transcriptomic clocks reveal cell proximity effects in brain ageing

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08334-8 A spatially resolved single-cell transcriptomics map of the mouse brain at different ages reveals signatures of ageing, rejuvenation and disease, including ageing effects associated with T cells and rejuve … | Continue reading


@nature.com | 28 days ago

Diatom phytochromes integrate the underwater light spectrum to sense depth

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08301-3 This study demonstrates that diatoms with phytochrome photoreceptors can detect and functionally respond to the entire visible light spectrum through these sensors, enabling them to sense depth and regulat … | Continue reading


@nature.com | 28 days ago

Trimodal thermal energy storage material for renewable energy applications

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08214-1 A eutectic phase change material composed of boric and succinic acids demonstrates a transition at around 150 °C, with a record high reversible thermal energy uptake and thermal stability over 1,000 heatin … | Continue reading


@nature.com | 28 days ago

229ThF4 thin films for solid-state nuclear clocks

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08256-5 Laser excitation of the 229Th isomer, potentially relevant for nuclear clocks, is reported in thorium fluoride thin films, which are less radioactive and amenable to integration compared with existing thor … | Continue reading


@nature.com | 28 days ago

The conformational space of RNase P RNA in solution

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08336-6 Using a deep neural network and statistical analyses of atomic force microscopy images of individual RNA molecules enables the mapping of RNA conformational space in solution. | Continue reading


@nature.com | 28 days ago

Lithocholic acid binds TULP3 to activate sirtuins and AMPK to slow down ageing

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08348-2 The molecular mechanism underlying how lithocholic acid recapitulates the lifespan and healthspan benefits of calorie restriction is revealed to involve TULP3, sirtuins, v-ATPase and AMPK. | Continue reading


@nature.com | 28 days ago

Lithocholic acid phenocopies anti-ageing effects of calorie restriction

Nature, Published online: 18 December 2024; doi:10.1038/s41586-024-08329-5 Lithocholic acid is one of the metabolites upregulated during calorie restriction, and treatment of mice, worms and flies with this bile acid alone can reproduce the health benefits of calorie restriction. | Continue reading


@nature.com | 28 days ago