Formation of a low-mass galaxy from star clusters in a 600-million-year-old Universe

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08293-0 JWST observations of a strongly lensed low-mass galaxy in a 600-million-year-old Universe show massive star clusters (the Firefly Sparkle) cocooned in a diffuse arc in the Canadian Unbiased Cluster Survey. | Continue reading


@nature.com | 1 month ago

Strong electron–phonon coupling in magic-angle twisted bilayer graphene

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08227-w Angle-resolved photoemission spectroscopy of superconducting magic-angle twisted bilayer graphene reveals flat-band replicas that are indicative of strong electron–phonon coupling; these replicas are absen … | Continue reading


@nature.com | 1 month ago

Sacrificial capillary pumps to engineer multiscalar biological forms

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08175-5 A patterning method using gallium-based engineered sacrificial capillary pumps for evacuation is described for generating structures in soft natural hydrogels across several length scales and enabling a wi … | Continue reading


@nature.com | 1 month ago

Haematological setpoints are a stable and patient-specific deep phenotype

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08264-5 Complete blood count indices are tightly regulated around setpoints for decades in healthy adults, and represent a deep phenotype providing opportunities for investigating differential disease risks, impro … | Continue reading


@nature.com | 1 month ago

X-ray linear dichroic tomography of crystallographic and topological defects

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08233-y A new non-destructive spectroscopic method, ptychographic X-ray linear dichroic orientation tomography, is described, allowing the intragranular and intergranular characterization of extended polycrystalli … | Continue reading


@nature.com | 1 month ago

The mechanism of mRNA cap recognition

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08304-0 Allosteric communication between the eIF4F subunits drives mRNA cap-recognition and subsequent activation of the message. | Continue reading


@nature.com | 1 month ago

π-HuB: the proteomic navigator of the human body

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08280-5 We introduce a major scientific endeavour called π-HuB (proteomic navigator of the human body), its aim being to generate and harness multimodality proteomic datasets to enhance our understanding of human … | Continue reading


@nature.com | 1 month ago

Crosslinking intermodular condensation in non-ribosomal peptide biosynthesis

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08306-y Structural studies of tyrocidine synthetase using site-selective crosslinking probes to link condensation domains with carrier protein substrates define key interactions and molecular mechanisms of non-rib … | Continue reading


@nature.com | 1 month ago

Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08320-0 The development of a first-in-class non-covalent small-molecule inhibitor of SARS-CoV-2 replication that targets the viral guanine-N7 methyltransferase NSP14 is reported. | Continue reading


@nature.com | 1 month ago

Continuous collective analysis of chemical reactions

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08211-4 Mass spectrometry fragmentation patterns define analytical barcodes for the rapid, quantitative analysis of high-throughput chemical synthesis experiments. | Continue reading


@nature.com | 1 month ago

Structure and assembly of the dystrophin glycoprotein complex

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08310-2 A structural study of native dystrophin glycoprotein complex from mouse skeletal muscle reveals an extended tower-like architecture that provides multiple binding sites on both sides of the membrane for si … | Continue reading


@nature.com | 1 month ago

Strong-field quantum control in the extreme ultraviolet domain using pulse shaping

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08209-y Ultrafast quantum control of helium atoms is obtained by shaping the extreme ultraviolet pulses generated by a seeded free-electron laser. | Continue reading


@nature.com | 1 month ago

Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08223-0 Cryo-electron microscopy structures of apolipoprotein B100 (apoB100) in complex with the LDL receptor (LDLR) provide insight into binding interfaces and explain how mutations in apoB100 or in LDLR can give … | Continue reading


@nature.com | 1 month ago

Large global-scale vegetation sensitivity to daily rainfall variability

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08232-z Satellite data and field observations show that global annual-scale vegetation indices are sensitive to the daily frequency and intensity of rainfall, independent of the total amount of rainfall per year. | Continue reading


@nature.com | 1 month ago

Self-organized patterning of crocodile head scales by compressive folding

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08268-1 Crocodile head scales self-organize through purely mechanical compressive skin folding rather than a patterning process controlled by gene interactions. | Continue reading


@nature.com | 1 month ago

Lithium extraction from low-quality brines

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08117-1 Precipitation, solvent extraction, sorption, membrane-based separation and electrochemical-based separation are described as promising methods for extracting lithium from low-quality brines, which have ext … | Continue reading


@nature.com | 1 month ago

Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08291-2 A platform for mRNA lipid nanoparticle delivery to the placenta to treat pre-eclampsia is shown to improve fetal and maternal health in mice and has potential clinical applications in obstetric disorders a … | Continue reading


@nature.com | 1 month ago

Native DGC structure rationalizes muscular dystrophy-causing mutations

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08324-w The detailed structure of the native dystrophin–glycoprotein complex provides mechanistic insights into mutations underlying muscular dystrophy. | Continue reading


@nature.com | 1 month ago

Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08305-z A study reporting the results of a clinical trial co-administering the GDF-15-blocking antibody visugromab with the anti-PD-1 antibody nivolumab demonstrates that neutralizing GDF-15 can overcome resistanc … | Continue reading


@nature.com | 1 month ago

Discovery and engineering of the antibody response to a prominent skin commensal

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08489-4 Discovery and engineering of the antibody response to a prominent skin commensal | Continue reading


@nature.com | 1 month ago

Structure and mechanism of the Zorya anti-phage defense system

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08493-8 Structure and mechanism of the Zorya anti-phage defense system | Continue reading


@nature.com | 1 month ago

The structure of apolipoprotein B100 from human low-density lipoprotein

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08467-w The structure of apolipoprotein B100 from human low-density lipoprotein | Continue reading


@nature.com | 1 month ago

Structures and mechanism of condensation in nonribosomal peptide synthesis

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08417-6 Structures and mechanism of condensation in nonribosomal peptide synthesis | Continue reading


@nature.com | 1 month ago

Skin autonomous antibody production regulates host-microbiota interactions

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08376-y Skin autonomous antibody production regulates host-microbiota interactions | Continue reading


@nature.com | 1 month ago

Aromatic ring-opening metathesis

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08472-z Aromatic ring-opening metathesis | Continue reading


@nature.com | 1 month ago

Accessibility worsens for blind and low-vision readers of academic PDFs

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-03953-7 Preprints and other rapid-publishing trends have fuelled a decline in scientific publications meeting accessibility standards, study finds. | Continue reading


@nature.com | 1 month ago

Betsy Donnelly’s forty-third chance

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04048-z A career high. | Continue reading


@nature.com | 1 month ago

Publisher Correction: An integrated transcriptomic cell atlas of human neural organoids

Nature, Published online: 11 December 2024; doi:10.1038/s41586-024-08482-x Publisher Correction: An integrated transcriptomic cell atlas of human neural organoids | Continue reading


@nature.com | 1 month ago

A little bird flies high thanks to mighty mitochondria

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-04010-z White-crowned sparrows can migrate thousands of kilometres after churning out energy-producing organelles. | Continue reading


@nature.com | 1 month ago

Better data sets won’t solve the problem — we need AI for Africa to be developed in Africa

Nature, Published online: 11 December 2024; doi:10.1038/d41586-024-03988-w Language models developed by big technology companies consistently underperform in African languages. It’s time to focus on local solutions. | Continue reading


@nature.com | 1 month ago

A featherweight baby planet is fading away with age

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-04011-y The gas planet has a density less than 2% that of Earth ― and is gradually shedding mass. | Continue reading


@nature.com | 1 month ago

Is the telescope pointing the right way?

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-03859-4 This week’s excerpts from Nature’s archive feature reviews of a visit to the Lick Observatory in California and a children’s adaptation of a book on anthropology. | Continue reading


@nature.com | 1 month ago

Governments are banning kids from social media: will that protect them from harm?

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-03955-5 Australia is the latest nation to introduce restrictions but evidence is limited about whether they will work. | Continue reading


@nature.com | 1 month ago

Daily briefing: What’s next for Syria’s science? A view from Nature’s reporter who was a refugee

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-04087-6 We meet the revolutionary economist who became the unlikely leader of Bangladesh and explore what’s next for Syria’s science. | Continue reading


@nature.com | 1 month ago

Why the genetic-testing revolution left some people behind — and what to do about it

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-04046-1 Thirty years after the sequencing of the BRCA1 cancer-associated gene, access to genetic tests and awareness about its risks are still too limited. | Continue reading


@nature.com | 1 month ago

Satellites are no silver bullet for methane monitoring

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-03987-x Detecting and interpreting methane emissions from space is not enough. A comprehensive approach is needed. | Continue reading


@nature.com | 1 month ago

How CRISPR patent issues block Indian farmers from accessing biotech benefits

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-03989-9 Scientists in Asia and Africa are racing to discover hardier crop varieties using gene editing tools. But patent restrictions come in the way. | Continue reading


@nature.com | 1 month ago

Ancient DNA data hold insights into past organisms and ecosystems — handle them with more care

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-03993-z DNA recovered from ancient remains is transforming our understanding of organisms and ecosystems from tens, thousands and even millions of years ago – but the growing volume of data must be better preserve … | Continue reading


@nature.com | 1 month ago

AI decodes the calls of the wild

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-04050-5 Artificial intelligence could reveal how animals of the land, sea and sky talk to others of their species. | Continue reading


@nature.com | 1 month ago

Claims that dam removals were to blame for Valencia floods are false

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-04060-3 Claims that dam removals were to blame for Valencia floods are false | Continue reading


@nature.com | 1 month ago

Stop digital platforms treating people as lab rats

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-04058-x Stop digital platforms treating people as lab rats | Continue reading


@nature.com | 1 month ago

Use existing foundations to build up citizen science for the SDGs

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-04057-y Use existing foundations to build up citizen science for the SDGs | Continue reading


@nature.com | 1 month ago

Large language models can help to translate science into real-world impact

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-04059-w Large language models can help to translate science into real-world impact | Continue reading


@nature.com | 1 month ago

Engineered cells take drugs deep into the brain ― and nowhere else

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-04008-7 Altered T cells, which have the ability to cross the blood–brain barrier, can deliver drugs straight to brain tumours. | Continue reading


@nature.com | 1 month ago

What should we do if AI becomes conscious? These scientists say it’s time for a plan

Nature, Published online: 10 December 2024; doi:10.1038/d41586-024-04023-8 Researchers call on technology companies to test their systems for consciousness and create AI welfare policies. | Continue reading


@nature.com | 1 month ago

Nine books to help shape your science career in 2025

Nature, Published online: 09 December 2024; doi:10.1038/d41586-024-03995-x Researchers seeking to banish workaholic behaviours, boost their pay, have more influence at work or quit academia will find plenty of advice in these books, all published this year. | Continue reading


@nature.com | 1 month ago

‘A truly remarkable breakthrough’: Google’s new quantum chip achieves accuracy milestone

Nature, Published online: 09 December 2024; doi:10.1038/d41586-024-04028-3 Error-correction feat shows quantum computers will get more accurate as they grow larger. | Continue reading


@nature.com | 1 month ago

The daring doctor behind a world-first treatment for autoimmune disease

Nature, Published online: 09 December 2024; doi:10.1038/d41586-024-03895-0 Huji Xu is part of Nature’s 10, a list of people who shaped science in 2024. | Continue reading


@nature.com | 1 month ago