Virtual lab powered by ‘AI scientists’ super-charges biomedical research

Nature, Published online: 04 December 2024; doi:10.1038/d41586-024-01684-3 Could human-AI collaborations be the future of interdisciplinary studies? | Continue reading


@nature.com | 1 month ago

Understanding the neural code of stress to control anhedonia

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08241-y Examination of the neural activity in the basolateral amygdala and ventral CA1 of mice during tasks or rest following exposure to social stress reveals signatures of resilience and susceptibility to stress … | Continue reading


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Dietary fructose enhances tumour growth indirectly via interorgan lipid transfer

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08258-3 Dietary fructose enhances tumour growth in animal models of melanoma, breast cancer and cervical cancer indirectly via metabolite transfer. | Continue reading


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Fetal hepatocytes protect the HSPC genome via fetuin-A

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08307-x A mechanism is uncovered that results in fetal hepatocytes having a paracrine role in providing genome protection to haematopoietic stem and progenitor cells. | Continue reading


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Near-identical macromolecules spontaneously partition into concentric circles

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08203-4 A particular liquid–liquid phase separation at a solid–liquid interface led to the unexpected partitioning of highly similar polymeric molecules into concentric circles. | Continue reading


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Evolution of myeloid-mediated immunotherapy resistance in prostate cancer

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08290-3 Single-cell profiling of human prostate cancer and studies in mouse models show that macrophages expressing SPP1 mediate immunotherapeutic resistance through adenosine pathway activation and represent a po … | Continue reading


@nature.com | 1 month ago

Probabilistic weather forecasting with machine learning

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08252-9 GenCast, a probabilistic weather model using artificial intelligence for weather forecasting, has greater skill and speed than the top operational medium-range weather forecast in the world and provides pr … | Continue reading


@nature.com | 1 month ago

New particle formation from isoprene under upper-tropospheric conditions

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08196-0 Experiments performed in the CERN CLOUD chamber show that, under upper-tropospheric conditions, new atmospheric particle formation may be initiated by the reaction of hydroxyl radicals with isoprene emitte … | Continue reading


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The oestrous cycle stage affects mammary tumour sensitivity to chemotherapy

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08276-1 In three mouse models of breast cancer, we show reduced responses to neoadjuvant chemotherapy when treatment is initiated during the dioestrus stage, when compared with initiation during the oestrus stage. | Continue reading


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Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08285-0 Studies using mouse models of lung adenocarcinoma identify an association between age, iron homeostasis and tumour initiation potential that involves NUPR1 and lipocalin-2. | Continue reading


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Fast ground-to-air transition with avian-inspired multifunctional legs

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08228-9 A bird-inspired robot that can jump into flight, walk on the ground and hop over obstacles shows that jumping for take-off is more energy efficient than taking off without the jump. | Continue reading


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Synthetic GPCRs for programmable sensing and control of cell behaviour

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08282-3 Modular synthetic G-protein-coupled receptors with nanobody-based ligand-recognition domains can be designed and used to programme transgene expression, real-time fluorescence or endogenous G-protein activ … | Continue reading


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Tracking transcription–translation coupling in real time

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08308-w Single-molecule fluorescence microscopy experiments with a recombinant Escherichia coli transcription–translation system provides insights into the coordination of the transcription and translation machine … | Continue reading


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Applied body-fluid analysis by wearable devices

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08249-4 A review of wearable devices for body-fluid analysis discusses the strategies, considerations and challenges to achieve their successful clinical translation and how they might contribute to solving some g … | Continue reading


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Isoprene nitrates drive new particle formation in Amazon’s upper troposphere

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08192-4 Aircraft measurements over the Amazon show that new particle formation in the upper troposphere emerges when isoprene, emitted by forests, undergoes oxidation in the presence of nitrogen oxides produced by … | Continue reading


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Macrophages excite muscle spindles with glutamate to bolster locomotion

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08272-5 A population of macrophages with exclusive molecular and functional signatures in the muscle spindles express machinery for synthesizing and releasing glutamate, and a cellular component, the muscle spindl … | Continue reading


@nature.com | 1 month ago

Mis-splicing of a neuronal microexon promotes CPEB4 aggregation in ASD

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08289-w The molecular mechanisms of how small changes in the degree of inclusion of a neuron-specific microexon in CPEB4 lead to dominant-negative effects in the expression of genes associated with autism spectrum … | Continue reading


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In situ spheroid formation in distant submillimetre-bright galaxies

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08201-6 Deep ALMA archival observations of submillimetre-bright galaxies at high redshifts show that spheroidal bulges formed much earlier than expected and are directly generated by star formation within the core … | Continue reading


@nature.com | 1 month ago

RANK drives structured intestinal epithelial expansion during pregnancy

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08284-1 The RANK–RANKL pathway drives intestinal epithelial expansion in pregnancy and lactation. | Continue reading


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Watch this bird-inspired drone leap into the air

Nature, Published online: 04 December 2024; doi:10.1038/d41586-024-03974-2 Lightweight mechanical legs enable this fixed-wing drone to navigate complicated terrain. | Continue reading


@nature.com | 1 month ago

Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08434-5 Author Correction: APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes | Continue reading


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Author Correction: A virally encoded tRNA neutralizes the PARIS antiviral defence system

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08427-4 Author Correction: A virally encoded tRNA neutralizes the PARIS antiviral defence system | Continue reading


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Author Correction: Carbon dioxide capture from open air using covalent organic frameworks

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08464-z Author Correction: Carbon dioxide capture from open air using covalent organic frameworks | Continue reading


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Author Correction: Autoregulation in rats with transplanted supernumerary kidneys

Nature, Published online: 04 December 2024; doi:10.1038/s41586-024-08461-2 Author Correction: Autoregulation in rats with transplanted supernumerary kidneys | Continue reading


@nature.com | 1 month ago

A step-by-step guide to landing your next job in science

Nature, Published online: 04 December 2024; doi:10.1038/d41586-024-03926-w A road map to success based on Nature’s hiring-in-science survey, with advice for every stage from application to offer. | Continue reading


@nature.com | 1 month ago

Exis memoria

Nature, Published online: 04 December 2024; doi:10.1038/d41586-024-03908-y Tales to tell. | Continue reading


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How to ensure only dying cells rupture

Nature, Published online: 04 December 2024; doi:10.1038/d41586-024-03851-y During some types of cell death, cells rupture to release molecules that cause inflammation. This must happen at the right time and place to restore health. How is the protein NINJ1 regulated so that cells … | Continue reading


@nature.com | 1 month ago

Why the EU must reset its Green Deal – or be left behind

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03918-w The world has changed since Europe’s ambitious climate package was designed. Here’s how the agreement should evolve. | Continue reading


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To unlock mutual benefits, don’t restrict US–China genome data transfer

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03947-5 To unlock mutual benefits, don’t restrict US–China genome data transfer | Continue reading


@nature.com | 1 month ago

China’s climate investments in Africa must promote mutual benefit

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03946-6 China’s climate investments in Africa must promote mutual benefit | Continue reading


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Public trust in science can be diminished by communicating uncertainty

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03948-4 Public trust in science can be diminished by communicating uncertainty | Continue reading


@nature.com | 1 month ago

Science must up its game to support climate finance negotiations

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03945-7 Science must up its game to support climate finance negotiations | Continue reading


@nature.com | 1 month ago

How close is AI to human-level intelligence?

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03905-1 Large language models such as OpenAI’s o1 have electrified the debate over achieving artificial general intelligence, or AGI. But they are unlikely to reach this milestone on their own. | Continue reading


@nature.com | 1 month ago

How I put LinkedIn to work for my career as a scientist and entrepreneur

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03865-6 Developmental psychologist and career consultant Ashley Ruba credits the networking platform with transforming her career. | Continue reading


@nature.com | 1 month ago

US academics: look after foreign students

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03912-2 The first Trump term took a toll on international scholars and collaborations — we can avoid similar pitfalls. | Continue reading


@nature.com | 1 month ago

Author Correction: Genetic drivers and cellular selection of female mosaic X chromosome loss

Nature, Published online: 03 December 2024; doi:10.1038/s41586-024-08215-0 Author Correction: Genetic drivers and cellular selection of female mosaic X chromosome loss | Continue reading


@nature.com | 1 month ago

What is ageing? Even the field’s researchers can’t agree

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03936-8 Survey of scientists who study ageing finds no consensus on the fundamentals. | Continue reading


@nature.com | 1 month ago

Where does poetry come from?

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03848-7 Surveying poets on the unconscious sources of their verse, and an accidental ghost co-author, in this week’s excerpts from Nature’s archive. | Continue reading


@nature.com | 1 month ago

A plastics treaty is urgently needed, but getting it right will take time

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03932-y Although the latest talks have ended without a final agreement, countries have pledged to continue talking — and that is no small achievement. | Continue reading


@nature.com | 1 month ago

A firm randomly assigned its scientists AI: here’s what happened

Nature, Published online: 03 December 2024; doi:10.1038/d41586-024-03939-5 Controlled study following more than 1,000 researchers at an unnamed materials-science company saw increases in discoveries and patents. | Continue reading


@nature.com | 1 month ago

Daily briefing: Homo erectus, I presume? Footprints show ancient hominins crossed paths

Nature, Published online: 02 December 2024; doi:10.1038/d41586-024-03966-2 Remarkably preserved footprints show two ancient human relatives crossed paths 1.5 million years ago. Plus, plastics-treaty negotiations end in stalemate and drug cartels are recruiting chemistry students … | Continue reading


@nature.com | 1 month ago

Great power and great responsibility: how consciousness changes the world

Nature, Published online: 02 December 2024; doi:10.1038/d41586-024-03916-y A vivid account of the evolution of minds will fill readers with wonder — and challenge how they think about their moral responsibility to protect the planet. | Continue reading


@nature.com | 1 month ago

The contentious genius who made black holes real

Nature, Published online: 02 December 2024; doi:10.1038/d41586-024-03917-x Roger Penrose, now 93, never shied away from wild ideas and the ensuring debates. The first full-length biography reveals more about the mathematician and the man. | Continue reading


@nature.com | 1 month ago

ChatGPT turns two: how the AI chatbot has changed scientists’ lives

Nature, Published online: 02 December 2024; doi:10.1038/d41586-024-03940-y How many researchers are using the AI tool? Nature gathers data and talks to members of the academic community. | Continue reading


@nature.com | 1 month ago

How provinces and cities can sustain US–China climate cooperation

Nature, Published online: 02 December 2024; doi:10.1038/d41586-024-03919-9 National politics is set to drastically shift in both countries. But avenues for joint action still exist. | Continue reading


@nature.com | 1 month ago

I help researchers to measure methane at a local level so that we can make global changes

Nature, Published online: 02 December 2024; doi:10.1038/d41586-024-03927-9 Ioannis Binietoglou makes sure that the latest technology reaches areas that need it. | Continue reading


@nature.com | 1 month ago

Daily briefing: How to get to 100 — centenarian cells teach us about ageing

Nature, Published online: 29 November 2024; doi:10.1038/d41586-024-03931-z A bank of centenarians’ cells are giving scientists a new resource for studying longevity. Plus, the month’s best science images and tips to help you unleash your scientific creativity. | Continue reading


@nature.com | 1 month ago

What’s the secret to living to 100? Centenarian stem cells could offer clues

Nature, Published online: 29 November 2024; doi:10.1038/d41586-024-03886-1 A bank of cells from people more than 100 years old gives scientists a new resource for studying longevity. | Continue reading


@nature.com | 1 month ago