In a screen of 324 human cancer cell lines and utilising a systematic target prioritization framework, the Werner syndrome ATP-dependent helicase is shown to be a synthetic lethal target in tumours from multiple cancer types with microsatellite instability, providing a new t … | Continue reading
Functional materials that act as bio-sensing media when interfaced with complex bio-matter are attractive for health sciences and bio-engineering. Here, the authors report room temperature enzyme-mediated spontaneous hydrogen transfer between a perovskite quantum material and glu … | Continue reading
Officials say inadequate funding and mistrust are hampering efforts to combat the outbreak. | Continue reading
COL17A1-driven stem cell competition and symmetric cell divisions initially govern skin homeostasis, but the same mechanisms result in skin ageing later in life. | Continue reading
Bone fragments reveal that a short-statured species — which researchers have named Homo luzonensis — lived more than 50,000 years ago. | Continue reading
Agriculture sustains a large and growing human population, but generates widespread impacts. This study assesses the health effects of air pollution caused by maize production. Reduced air quality leads to 4,300 premature deaths annually in the United States, akin to US$39 billio … | Continue reading
A new-found snapshot of extinction highlights a mystery that scientists are still working to solve. | Continue reading
Graham Farmelo parses Lee Smolin’s takedown of the most successful physics theory ever. | Continue reading
Researchers in the United States have developed a method to create nanopores smaller than 10 nanometers in a simple, controllable, cost-effective way. Sunggook Park’s team at Louisiana State University pressed an array of silicon microneedles into a polymer layer to produce pores … | Continue reading
Negative capacitance describes a phenomenon where the increase in the charge of the capacitor results in decreasing its voltage. The authors put forth a ferroelectric nanodot harboring two polarization domains which stabilize static reversible negative capacitance. | Continue reading
The authors develop a noninvasive stimulation protocol to restore neural synchronization patterns and improve working memory in older humans, contributing to groundwork for future drug-free therapeutics targeting age-related cognitive decline. | Continue reading
Deep brain stimulation (DBS) is a promising treatment for psychiatric disorders, but its mechanism in relieving symptoms is unclear. Here, the authors show that DBS of ventral internal capsule/ventral striatum (VCVS) may act by enhancing prefrontal cortex oscillations that in tur … | Continue reading
Amelia Hennighausen extols a tome on how ever-evolving photography has captured the glory of scientific phenomena. | Continue reading
Nobel-prizewinning biologist pioneered use of C. elegans as an animal model. | Continue reading
Artificial intelligence is everywhere. But before scientists trust it, they first need to understand how machines learn. | Continue reading
Particles' changing masses could explain why distant galaxies appear to be rushing away. | Continue reading
Controlling droplet impact and rebound behaviour can have applications in inkjet printing and self-cleaning. Here the authors show how a chemically-patterned surface with high-adhesive spirals surrounded by hydrophobic, low-adhesive regions leads to gyration behaviour of impactin … | Continue reading
The authors report the first-in-human application of personalized neo-antigen RNA vaccines in patients with melanoma. | Continue reading
Yoshua Bengio, winner of the prestigious Turing award for his work on deep learning, is establishing international guidelines for the ethical use of AI. | Continue reading
Behavioural experiments suggest that felines acknowledge their monikers by subtly moving their heads and ears. | Continue reading
Scientists are optimistic that innovative techniques can pinpoint the true origin of timber. | Continue reading
Why Germany is becoming a career destination for many researchers. | Continue reading
A quirk in how Global Positioning System signals are time-stamped risks messing up devices’ data from 6 April. | Continue reading
Decades after weapons testing stopped, researchers are still struggling to decipher the health impacts of radiation exposure around Semipalatinsk. | Continue reading
Chromatophores in cephalopod skin are known for fast changes in coloration due to light-scattering pigment granules. Here, authors demonstrate structural coloration facilitated by reflectin in sheath cells and offer insights into the interplay between structural and pigmentary co … | Continue reading
The disastrous process of leaving the European Union is creating casualties of science and communities. | Continue reading
The discoveries could guide a new era of lunar exploration. | Continue reading
Sex-stratified medicine is an important and understudied field. Here the authors investigate in a systematic study of the Danish population differences in incidence, risk, and several aspects of diagnoses between sexes and find differences across all areas of disease. | Continue reading
The surprise finding that neurogenesis drops in diseased brains could throw open a new route to therapies. | Continue reading
Evelyn Lamb enjoys a rich study on number-crunching and its ubiquitous fruit. | Continue reading
Genetic studies of today’s tea plants are providing clues to how the plant was first domesticated. | Continue reading
Laser and particle system produces three-dimensional moving images that appear to float in thin air. | Continue reading
NASA mission finds asteroid Bennu littered with big boulders and spraying out particles. | Continue reading
White House policy will require universities to certify that they protect free speech to remain eligible for research funding. | Continue reading
White House policy will require universities to certify that they protect free speech to remain eligible for research funding. | Continue reading
Researchers are hijacking the cell’s protein-disposal system in the fight against Alzheimer’s and intractable cancers. | Continue reading
Researchers are hijacking the cell’s protein-disposal system in the fight against Alzheimer’s and intractable cancers. | Continue reading
The technique could help boys made infertile by cancer treatment to become fathers later in life. | Continue reading
Researchers are reaping the benefits of carefully built programmes and a surge in funding. | Continue reading
Belief in moralizing gods followed the expansion of human societies and may have been preceded by doctrinal rituals that contributed to the initial rise of social complexity. | Continue reading
A set of 355 self-assembling DNA ‘tiles’ can be reprogrammed to implement many different computer algorithms—including sorting, palindrome testing and divisibility by three—suggesting that molecular self-assembly could be a reliable algorithmic component in programmable chemical … | Continue reading