eLife is changing its editorial process to emphasize public reviews and assessments of preprints by eliminating accept/reject decisions after peer review. | Continue reading
Tumors escape killing by the immune system through generating transient spatial cell-in-cell structures that are impenetrable to cytotoxic compounds including lytic granules and chemotherapy. | Continue reading
Model-based fMRI reveals the neurocomputational bases of accepting a bribe when power-holders consider two moral costs, conniving with a fraudulent briber and the harm brought to a third party. | Continue reading
Analysis of UK Biobank data from 20,000 people shows that diabetes speeds up the normal process of brain aging, with longer duration of diabetes linked to increased neurodegeneration. | Continue reading
Physiological evidence shows that the pupillary response to imagined light can be used to index the strength and vividness of an individual’s visual imagery and as a new tool for confirming aphantasia. | Continue reading
The availability of almost all articles from toll access journals in the Sci-Hub repository will disrupt scholarly publishing towards more open models. | Continue reading
Phylogenetic and computational methods reveal that at least two seasonal coronaviruses are evolving adaptively in the region of the viral spike protein exposed to the human humoral immune system. | Continue reading
The anecdotally reported benefits of psychedelics microdosing can be explained by the placebo effect. | Continue reading
Interaction of oncoprotein transcription factor MYC with chromatin-associated protein host cell factor–1 controls expression of genes important for ribosome biogenesis and mitochondrial vigor, loss of which promotes tumor regression. | Continue reading
Cognitive effort is aversive and people will accept physical pain to avoid it, but this avoidance does not appear to share the same fundamental characteristics of pain avoidance. | Continue reading
From July 2021 eLife will only review manuscripts already published as preprints, and will focus its editorial process on producing public reviews to be posted alongside the preprints. | Continue reading
A novel, overlapping, putatively functional gene in SARS-CoV-2, ORF3d, is absent from close relatives of SARS-CoV-2 and may have contributed to the biology, emergence, or spread of the virus. | Continue reading
Walking flies find the source of attractive odors by changing how frequently they stop and turn in response to the smell. | Continue reading
A previously unrecognized group of metalloenzymes enables human gut microbes to metabolize dietary molecules and neurotransmitters and likely mediates interactions and metabolism among environmental microorganisms. | Continue reading
A novel CRISPR-based genetic screen of candidate regeneration genes in haploid axolotl limbs reveals two genes required for proper regeneration. | Continue reading
The newborn infant experience of pain closely resembles that observed in adults, suggesting that infants have the sensory and emotional capacity to experience pain. | Continue reading
Since the Industrial Revolution, normal body temperature in both men and women has decreased monotonically by 0.03°C per birth decade. | Continue reading
The nucleoplasm surrounding nucleoli in living cells plays a key role in nucleolar dynamics and shape fluctuations in vivo. | Continue reading
Michael Eisen, eLife’s Editor-in-Chief, reflects on lessons learned from a recent peer-review trial, and describes how eLife aims to make peer review more effective. | Continue reading
Exposure to chronic adversity in childhood and adulthood can lead to a dampened physiological response to acute stress and exaggerated threat perception. | Continue reading
Bacteria growing in biofilms evolve antimicrobial resistance via different pathways and generate greater genetic diversity than well-mixed populations, selecting fitter but less resistant genotypes. | Continue reading
Conservative mutations within a secondary active transport protein influenced the conformational equilibrium probed using NMR spectroscopy which correlated to the functional output in vivo. | Continue reading
What can authors and reviewers do to keep common statistical mistakes out of the literature? | Continue reading
New mutations appear in the sperm and eggs of parents, or very early in the developing embryo at different rates depending on the family. | Continue reading
Dsup, a unique protein found only in tardigrades, is a nucleosome-binding protein that protects DNA from damage by hydroxyl radicals, such as those generated by ionizing radiation or oxidants. | Continue reading
Measurements of bar-headed geese flying in a wind tunnel in hypoxia reveal that these birds sustain aerobic flight at high altitude via a reduction in metabolism. | Continue reading
Animals living alongside humans have multiple copies of the gene for alpha-amylase, the enzyme that breaks down starchy foods, and high levels of this protein in their saliva. | Continue reading
An analysis of more than 3000 randomized controlled trials published in JAMA, the Lancet and NEJM has identified 396 medical reversals. | Continue reading
To protect their food and themselves against detrimental mould fungi, the eggs of a wasp species synthesize and emit remarkable amounts of gaseous nitrogen oxides that are highly effective antimicrobials. | Continue reading
As he prepares to step down as the Editor-in-Chief of eLife, Randy Schekman reflects on the origins of the journal, the eLife approach to peer review, and current challenges in scientific publishing. | Continue reading
The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools. | Continue reading
Stencila launches the first version of its word processor and spreadsheet editor designed for researchers. | Continue reading
There should be a prominent place for theory within biology papers, both as Results in papers that combine experiment and theory, and as Results in theory papers. | Continue reading
In an era in which evidence is being disregarded, scientists need to speak up in support of the pursuit for truth. | Continue reading
Low-frequency electrical waves in the stomach seem to be synchronised with the activity of a newly discovered resting-state network in the human brain. | Continue reading