Background and Objectives: While there is growing evidence that physical activity promotes neuronal health, studies examining the relation between physical activity and brain morphology remain inconclusive. We therefore examined whether objectively-quantified physical activity is … | Continue reading
Objective To determine how a vegetarian diet affects stroke incidence in 2 prospective cohorts and to explore whether the association is modified by dietary vitamin B12 intake.Methods Participants without stroke in the Tzu Chi Health Study (cohort 1, n = 5,050, recruited in 2007– … | Continue reading
I am writing to share a story with you, specifically for you. My hope is that it will help you understand your patients along with their spouses and caregivers a little more. And as for the research you do, perhaps this will add a few more faces behind the why you do what you do. … | Continue reading
Objective Disrupted sleep increases CSF levels of tau and β-amyloid (Aβ) and is associated with an increased risk of Alzheimer disease (AD). Our aim was to determine whether acute sleep loss alters diurnal profiles of plasma-based AD-associated biomarkers.Methods In a 2-condition … | Continue reading
Objective To investigate the associations of sleep duration, midday napping, sleep quality, and change in sleep duration with risk of incident stroke and stroke subtypes.Methods Among 31,750 participants aged 61.7 years on average at baseline from the Dongfeng-Tongji cohort, we u … | Continue reading
Objective To examine the associations of individual insomnia symptoms with risks of incident cardio-cerebral vascular diseases (CVD) and possible moderating factors among Chinese adults.Methods The China Kadoorie Biobank is a prospective cohort study that recruited participants f … | Continue reading
Objective We examined whether plasma β-amyloid (Aβ)42/Aβ40, as measured by a high-precision assay, accurately diagnosed brain amyloidosis using amyloid PET or CSF p-tau181/Aβ42 as reference standards.Methods Using an immunoprecipitation and liquid chromatography–mass spectrometry … | Continue reading
Objective To assess the association between exposure to monotherapy with 10 different antiepileptic drugs (AEDs) during the first 2 months of pregnancy and the risk of 23 major congenital malformations (MCMs).Methods This nationwide cohort study, based on the French health care d … | Continue reading
Objective To examine the association of body mass index (BMI) and waist-to-hip ratio (WHR) with brain volume.Methods We used cross-sectional data from the UK Biobank study (n = 9,652, age 55.4 ± 7.5 years, 47.9% men). Measures included BMI, WHR, and total fat mass as ascertained … | Continue reading
Objective To examine the association of body mass index (BMI) and waist-to-hip ratio (WHR) with brain volume.Methods We used cross-sectional data from the UK Biobank study (n = 9,652, age 55.4 ± 7.5 years, 47.9% men). Measures included BMI, WHR, and total fat mass as ascertained … | Continue reading
Objective To assess sociodemographic, socioeconomic, and clinical correlates of idiopathic REM sleep behavior disorder (RBD) in a 30,097-person national cohort.Methods Participants 45 to 85 years of age in Canada were collected as part of the Canadian Longitudinal Study on Aging. … | Continue reading
Objective To examine associations of orthostatic hypotension (OH) with dementia and long-term cognitive decline and to update previously published results in the same cohort for stroke with an additional 16 years of follow-up.Methods We analyzed data from 11,709 participants with … | Continue reading
I am writing to share a story with you, specifically for you. My hope is that it will help you understand your patients along with their spouses and caregivers a little more. And as for the research you do, perhaps this will add a few more faces behind the why you do what you do. … | Continue reading