The need for antimalarial drugs is urgent in the face of growing resistance to existing therapies. Murithi et al. characterized MMV688533, an acylguanidine identified from compounds inhibiting known human drug targets that were screened for activity against Plasmodium falciparum … | Continue reading
Estrogen receptor–positive breast cancer is the most common type of breast cancer and, in its metastatic form, is currently incurable. In a new study, Boudreau et al . describe a compound, ErSO, that can activate the unfolded protein response, resulting in necrosis of human breas … | Continue reading
Wolfram syndrome is a recessive genetic disease caused by mutations in WFS1 (Wolfram syndrome 1) and can present with a multitude of symptoms including diabetes, optic atrophy, and neurological problems. There is currently no cure and patients are managed with symptomatic treatme … | Continue reading
Huntington’s disease is a neurodegenerative disorder caused by a dominant mutation in the HTT gene, resulting in production of mutant huntingtin protein (mHTT). Deletion of mHTT specifically from astrocytes slowed disease progression. Now, Diaz-Castro et al. determined astrocyte … | Continue reading
Injuries to peripheral nerves that result in small gaps can heal after reapproximation; however, large gaps that occur after severe injuries require autograft implantation. As an alternative to autografts, Fadia et al . developed biodegradable polymer scaffolds that release a neu … | Continue reading
Understanding the dynamic of the two major hallmark of Alzheimer’s disease (AD), tau protein and β-amyloid, in the brain could allow better disease management. The use of positron emission tomography (PET) with specific radiotracers allows the visualization of tau-containing neur … | Continue reading
Light-activated molecular nanomachines can resensitize antibiotic-resistant bacteria to antibiotics by drilling holes in their cell wall. | Continue reading
The blood-brain barrier (BBB) regulates the communication between the vasculature and the brain. Aging and neurological disorders have been associated with BBB defects. Now, Milikovsky et al. and Senatorov et al. studied the consequences of BBB impairments in aging and disease. M … | Continue reading
The blood-brain barrier (BBB) regulates the communication between the vasculature and the brain. Aging and neurological disorders have been associated with BBB defects. Now, Milikovsky et al . and Senatorov et al . studied the consequences of BBB impairments in aging and disease. … | Continue reading
The mechanisms mediating age-related muscle atrophy are not completely understood. Now, Traoré et al . used mouse models to elucidate the mechanisms mediating age-related muscle atrophy. The authors first showed that muscle denervation triggered compensatory mechanisms to counter … | Continue reading
Sleep is crucial for healthy living and well-being. Sleep need varies greatly among people; however, little is known about the processes regulating sleep duration, continuity, and depth. Here, Xing et al. performed whole exome sequencing in a family of short sleepers and identifi … | Continue reading
We have developed an injectable foam suspension containing self-assembling, lipid-based microparticles encapsulating a core of pure oxygen gas for intravenous injection. Prototype suspensions were manufactured to contain between 50 and 90 ml of oxygen gas per deciliter of suspens … | Continue reading
Positron emission tomography (PET) using the radioligand for tau protein flortaucipir is a recently developed noninvasive method for measuring tau protein deposition. Although traumatic brain injury (TBI) has been associated with increased tau in postmortem samples, the long-term … | Continue reading
The field of digital medicine has matured over the past decade, but validation will require careful randomized, controlled clinical trials. | Continue reading
Circulating tumor cells in patients’ blood can offer insight into the underlying tumor and can also seed distant metastases. Thus, accurate detection of these cells could help with prediction of metastasis, as well as facilitate their elimination. Unfortunately, conventional meth … | Continue reading
Misfolded α-synuclein is a pathological hallmark of Parkinson’s disease (PD). Killinger et al . now report that the human appendix contains an abundance of misfolded α-synuclein and that removal of the appendix decreased the risk of developing PD. The appendix of both PD cases an … | Continue reading
Although a surgeon’s goal is to remove cancer in its entirety during excision surgery, achieving negative margins (absence of cancer cells at the outer edge of the excised tumor specimen) can be challenging. To facilitate intraoperative diagnosis, Zhang et al. developed a handhel … | Continue reading
Antimicrobials are ubiquitous in manufactured products beyond hand soap and exist in the environment as pollutants. Triclosan exposure is practically unavoidable in the United States, but little is known how ingestion may affect our health. Yang and colleagues used mouse models o … | Continue reading