Scientists have designed compounds that hit the same key receptor that LSD activates without causing hallucinations. A single dose produced powerful antidepressant and antianxiety effects in mice that lasted up to two weeks. | Continue reading
Scientists at UC San Francisco and Imperial College London found that psilocybin fosters greater connections between different regions of the brain in depressed people, freeing them up from long-held patterns of rumination and excessive self-focus. | Continue reading
Consuming high levels of red meat or white poultry resulted in higher blood cholesterol levels than consuming a comparable amount of plant proteins. | Continue reading
Over the past four decades, UCSF has led the way in its heroic response to the AIDS epidemic, both locally and globally. This timeline covers some of the highlights at UCSF, in the nation and around the world after a mysterious disease affecting gay men was first reported on June … | Continue reading
Research has shown that poor heart health can increase the risk for dementia, but a new study shows that poor mental health in early adulthood may increase odds by 73%. | Continue reading
UCSF Health physicians have successfully treated a patient with severe depression by tapping into the specific brain circuit involved in depressive brain patterns and resetting them using the equivalent of a pacemaker for the brain. | Continue reading
In a new study, an artificial intelligence algorithm exceeded the performance of a widely available commercial system in nearly all examined diagnoses. | Continue reading
A study in patients with epilepsy is helping researchers understand how the brain manages the task of learning a new language while retaining our mother tongue. | Continue reading
Researchers at UC San Francisco have successfully developed a “speech neuroprosthesis” that has enabled a man with severe paralysis to communicate in sentences, translating signals from his brain to the vocal tract directly into words that appear as text on a screen. | Continue reading
Insomnia is miserable, and lost sleep can harm our health. Now, researchers are seeing the promise of solutions in our genes. | Continue reading
Scientists have figured out how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into what’s known as the epigenome. | Continue reading
The new Institute will bring together scientists and clinicians from all UCSF sites to address the most critical questions related to the science of aging. | Continue reading
A UCSF team has engineered a tiny antibody capable of neutralizing the coronavirus. | Continue reading
In two preclinical models of COVID-19, plitidepsin showed a 100-fold reduction in viral replication in the lungs and demonstrated an ability to reduce lung inflammation. | Continue reading
Depression is among the most common psychiatric disorders, affecting as many as 264 million people worldwide and leading to hundreds of thousands of deaths per year. But as many as 30 percent of patients do not respond to standard treatments such as medication or psychotherapy. | Continue reading
The device, which may be a better illness indicator than a thermometer, could lead to earlier isolation and testing, curbing the spread of infectious diseases. | Continue reading
In the new study, UCSF researchers showed rapid restoration of youthful cognitive abilities in aged mice, accompanied by a rejuvenation of brain and immune cells that could help explain improvements in brain function. | Continue reading
UCSF scientists have developed a single clinical laboratory test capable of zeroing in on the microbial miscreant afflicting a patient in as little as six hours. | Continue reading
The study found no significant difference between the two groups in total weight loss or in other health markers. | Continue reading
The program will be one of the most comprehensive of its kind in the nation. | Continue reading
UCSF scientists have devised a novel approach to halting the spread of SARS-CoV-2, the virus that causes the disease. | Continue reading
UCSF researchers are taking a closer look at COVID-19’s dizzying array of symptoms to get at the disease’s root causes. | Continue reading
UCSF researchers are taking a closer look at COVID-19’s dizzying array of symptoms to get at the disease’s root causes. | Continue reading
UCSF researchers are taking a closer look at COVID-19’s dizzying array of symptoms to get at the disease’s root causes. | Continue reading
UCSF IT staff detected a security incident that occurred in a limited part of the UCSF School of Medicine’s IT environment on June 1. | Continue reading
One month after learning, new myelin (green) has been added to existing myelination (magenta) in the medial prefrontal cortex of an adult mouse. | Continue reading
Widely used organoid models fail to replicate even basic features of brain development and organization, much less the complex circuitry needed to model complex brain diseases or normal cognition. | Continue reading
English and Italian speakers with dementia-related language impairment experience distinct kinds of speech and reading difficulties based on features of their native languages. | Continue reading
We are entering an era of brain-machine interfaces and genome-editing technology. When we can govern the very biology that makes us who we are, what will it mean to be human? | Continue reading
After phages infect bacteria, they construct an impenetrable “safe room” inside of their host, which protects vulnerable phage DNA from antiviral enzymes. This compartment, which resembles a cell nucleus, is the most effective CRISPR shield ever discovered in viruses. | Continue reading
UCSF scientists who identified the only human gene known to promote “natural short sleep” have discovered a second. | Continue reading
Patients increasingly resort to crowdfunding websites to pay medical bills, a new UCSF study finds that online donations are sought for lost wages, child care and even occasionally experimental treatments. | Continue reading
Researchers discovered a scorpion toxin that targets the “wasabi receptor,” which they think it can be used as a tool for studying chronic pain and inflammation, and may eventually lead to the development of new kinds of non-opioid pain relievers. | Continue reading
The UCSF study examined whether a mobile phone physical activity app combined with brief, in-person counseling increased and maintained levels of physical activity | Continue reading
UCSF researchers programmed a machine-learning algorithm to diagnose early-stage Alzheimer’s disease. The algorithm used PET scans – a common type of brain scan. | Continue reading
The sugar industry has driven decades of biased research that shirk sugar's responsibility for chronic disease. UCSF researchers are uncovering thousands of industry documents to combat this misinformation, and steer Americans away from what is becoming a growing health crisis. | Continue reading
Peter Walter, PhD, professor of biochemistry and biophysics at UCSF, has been named winner of a 2018 Breakthrough Prize in Life Sciences, for his research on a biological mechanism that normally protects cells, but can cause disease if not functioning properly. | Continue reading
New review of nutritional science argues most American diets are deficient in a key class of vitamins and minerals. | Continue reading
UCSF scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail. | Continue reading
In an achievement that has significant implications for research, medicine, and industry, UCSF scientists have genetically reprogrammed human immune cells without using viruses to insert DNA | Continue reading